![]() What Else You Need to Know: Medicines that alter the serotonin levels can cause serotonin syndrome, with symptoms that include confusion, agitation, vomiting, diarrhea, tremor, shivering, muscle rigidity, rapid heartbeat and high blood pressure. ![]() Possible side effects may include nausea, headache, fatigue, high blood pressure, racing heart, excessive sweating, agitation, cholesterol and triglyceride elevation and tremor. These medicines may increase the risk of suicidal thinking in some people. The SNRIs used for fibromyalgia include duloxetine ( Cymbalta), Milnacipran ( Savella) and venlafaxine ( Effexor XR).īenefits and Risks: SNRIs protect the level of “feel good” chemicals (such as serotonin) available to the brain to help relieve depression, anxiety and pain. They affect the levels of brain chemicals that influence emotions and pain. Always read the full prescribing information when starting a new medication. Tell your doctor about all medicines you are taking, including over-the-counter drugs. The risks, side effects, and warnings listed below are not complete and you may experience more than these effects. Some of those drugs are antidepressants but that doesn’t mean that getting a prescription for your fibromyalgia means you are depressed. Others are used “off-label” – meaning, they’re used by doctors because of observed benefits but are not FDA-approved for fibromyalgia. Drugs such as NSAIDs, opioids and corticosteroids have not been found to be effective for fibromyalgia pain.ĭuloxetine ( Cymbalta), milnacipran ( Savella) and pregabalin ( Lyrica) are FDA-approved to specifically treat fibromyalgia. They can also help reduce fatigue, improve mood, promote sleep and ease other problems associated with fibromyalgia, including irritable bowel and restless legs syndromes. Many drugs prescribed for fibromyalgia work to turn down “pain volume” in the central nervous system (CNS). The most helpful treatment approach for fibromyalgia is a combination of self-care, physical activity and cognitive-behavioral therapy. ![]()
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